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Locked nucleic acid (LNA) Probes
LNAs are modified RNA bases in which the ribose is “locked” with a methylene bridge, connecting the 2′ oxygen atom to the 4′ carbon atom, fixing it in the C3′-endo conformation. Improve assay sensitivity and specificity with these probes from LCG Biosearch.
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Product Details
Improve assay sensitivity and specificity with locked nucleic acid (LNA) oligonucleotides. LNAs are modified RNA bases in which the ribose is “locked” with a methylene bridge, connecting the 2′ oxygen atom to the 4′ carbon atom, fixing it in the C3′-endo conformation.
The LNA’s have a shorter probe which means:
- Improved assay sensitivity
- Higher quenching efficiency (lower background)
- Greater signal-to-noise ratio
- Increased hybridisation specificity
- Targeting A-T rich sequences
- Better mismatch discrimination in SNP genotyping assays
Read more about the LNA probes here
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